abstract：:This study assessed visuospatial attention in healthy adults and medicated schizophrenic patients. Participants performed a visual orientation task in which a peripheral cue was followed. at different intervals, by a target presented either at valid or invalid locations. When the long stimulus onset asynchrony (SOA) w...

journal_title：Schizophrenia research

authors： Fuentes LJ,Boucart M,Alvarez R,Vivas AB,Zimmerman MA

更新日期：1999-11-09 00:00:00

abstract：:The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Br. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Hand and Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests that the typical pattern of human cerebral and manual asymmetries depends on a single gene (RS+) wh...

journal_title：Schizophrenia research

authors： Annett M

更新日期：1999-10-19 00:00:00

abstract：:Schizophrenia and affective disorders are relatively common neuropsychiatric diseases with a complex genetic etiology. A multigenic inheritance with variable influence of unknown environmental factors may be involved. Family studies have demonstrated the existence of both phenotypes in the same kindreds, and in certai...

journal_title：Schizophrenia research

authors： Wildenauer DB,Schwab SG,Maier W,Detera-Wadleigh SD

更新日期：1999-09-29 00:00:00

abstract：:The accuracy of the WAIS-R seven subtest short form (Ward, L.C., 1990. Prediction of Verbal, Performance and Full Scale IQs from seven subtests of the WAIS-R. J. Clin. Psychol. 46, 436-440) was examined for predicting IQs of 73 inpatients diagnosed with schizophrenia. Results indicated that 93% of the estimated Full S...

journal_title：Schizophrenia research

authors： Ryan JJ,Weilage ME,Spaulding WD

更新日期：1999-08-23 00:00:00

abstract：:Recent studies of cerebral pathology in patients with schizophrenia have focused on symptomatological and electrophysiological correlates of reduced temporal lobe structure volumes. Volume deficits of the left superior temporal gyrus have been correlated with auditory hallucinations as well as to left-sided P300 ampli...

journal_title：Schizophrenia research

authors： Havermans R,Honig A,Vuurman EF,Krabbendam L,Wilmink J,Lamers T,Verheecke CJ,Jolles J,Romme MA,van Praag HM

更新日期：1999-08-17 00:00:00

abstract：:Patients with schizophrenia did not take significantly more trials than normal controls to learn to use a visual warning signal to avoid a non-aversive stimulus on a simple computer-administered avoidance learning task. When the stimulus to be avoided was aversive (i.e., a loud buzzer), however, the schizophrenic grou...

journal_title：Schizophrenia research

authors： Kosmidis MH,Breier A,Fantie BD

更新日期：1999-07-27 00:00:00

abstract：:Noises elicit startle blinks that are inhibited when immediately (approximately 100 ms) preceded by non-startling prepulses, perhaps reflecting automatic sensory gating. Startle blinks are facilitated when preceded by prepulses at longer lead intervals, perhaps reflecting strategic processes. Event-related brain poten...

journal_title：Schizophrenia research

authors： Ford JM,Roth WT,Menon V,Pfefferbaum A

更新日期：1999-05-25 00:00:00

abstract：:Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...

journal_title：Schizophrenia research

authors： Loeber RT,Sherwood AR,Renshaw PF,Cohen BM,Yurgelun-Todd DA

更新日期：1999-05-04 00:00:00

abstract：:Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...

journal_title：Schizophrenia research

authors： Dixon L

更新日期：1999-03-01 00:00:00

abstract：:Various theories have been proposed to account for poor insight in schizophrenia. This study examined the relationships between insight, mood, schizophrenic symptoms and cognitive functioning. The relationship between longitudinal changes in insight and changes in symptoms and mood was also investigated. One-hundred p...

journal_title：Schizophrenia research

authors： Carroll A,Fattah S,Clyde Z,Coffey I,Owens DG,Johnstone EC

更新日期：1999-02-15 00:00:00

abstract：:The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive cha...

journal_title：Schizophrenia research

authors： Ortakov V,Mancevski B,Keilp J,Oppenheim S,Dwork AJ

更新日期：1999-01-11 00:00:00

abstract：:We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine functio...

journal_title：Schizophrenia research

authors： Hietala J,Syvälahti E,Vilkman H,Vuorio K,Räkköläinen V,Bergman J,Haaparanta M,Solin O,Kuoppamäki M,Eronen E,Ruotsalainen U,Salokangas RK

更新日期：1999-01-04 00:00:00

abstract：:Although the seasonal patterns of admissions of affective disorder have been extensively studied, less attention has been given to the seasonal admission patterns of schizophrenia. The traditional method of aggregating the data over a study period, rather than analysing by year of admission may obscure potentially rel...

journal_title：Schizophrenia research

authors： Clarke M,Moran P,Keogh F,Morris M,Kinsella A,Walsh D,Larkin C,O'Callaghan E

更新日期：1998-11-30 00:00:00

abstract：:Although factor scores are commonly used to interpret the Weschsler Adult Intelligence Scale--Revised (WAIS-R), the WAIS-R factor structure has not been investigated in patients with schizophrenia. We used confirmatory factor analysis (CFA) to examine five latent construct models in 169 males with schizophrenia. The W...

journal_title：Schizophrenia research

authors： Allen DN,Huegel SG,Seaton BE,Goldstein G,Gurklis JA Jr,van Kammen DP

更新日期：1998-11-09 00:00:00

abstract：:An earlier age at onset of schizophrenia in men as opposed to women, has been widely reported, but hitherto, insufficient account has been taken of parameters that might confound this finding. Furthermore, few explanatory models have accounted for the differences in shape of the age-at-onset distributions in males and...

journal_title：Schizophrenia research

authors： Castle D,Sham P,Murray R

更新日期：1998-10-09 00:00:00

abstract：:The objective of this study was to compare the efficacy and reliability of sertraline versus imipramine in the treatment of postpsychotic depressive disorder of schizophrenia. The diagnosis was based on DSM-IV research criteria. The Sympson-Angus Scale and SANS were performed in order to discriminate between depressiv...

journal_title：Schizophrenia research

authors： Kirli S,Caliskan M

更新日期：1998-09-07 00:00:00

abstract：:Low birth weight and preterm birth are important predictors of infant mortality and morbidity, and may increase the risk of schizophrenia. These adverse outcomes of pregnancy could be associated, therefore, with increased risk in children genetically predisposed to schizophrenia. The aim of this review was to describe...

journal_title：Schizophrenia research

authors： Bennedsen BE

更新日期：1998-09-07 00:00:00

abstract：:The Positive and Negative Syndrome Scale (PANSS) is employed increasingly for the evaluation of therapeutic outcome in studies on schizophrenia. Rater training is important to improve the concordance and accuracy of ratings; however, there are no established guidelines for carrying out such training. We conducted rate...

journal_title：Schizophrenia research

authors： Müller MJ,Rossbach W,Dannigkeit P,Müller-Siecheneder F,Szegedi A,Wetzel H

更新日期：1998-08-17 00:00:00

abstract：:Schizophrenic delusions are important target symptoms for treatment. This study aims to identify predictors of delusion formation. Two samples of schizophrenic patients (total n = 131) are examined prospectively every second week during a period of 6 months. In one sample (n = 60) delusion formation (n = 27; 45%) is c...

journal_title：Schizophrenia research

authors： Jørgensen P

更新日期：1998-06-22 00:00:00

abstract：:Currently, little is known about the pharmacological effects of the new generation of antipsychotic medications on perception of emotion in schizophrenia. The present study was designed to compare the effects of risperidone versus haloperidol on the ability to perceive emotion in 20 treatment-resistant schizophrenia p...

journal_title：Schizophrenia research

authors： Kee KS,Kern RS,Marshall BD Jr,Green MF

更新日期：1998-05-25 00:00:00

abstract：:The purpose of this study was to examine the concurrent validity of a Wechsler Adult Intelligence Scale-Revised (WAIS-R) seven subtest short form. Researchers have shown that the IQ scores estimated by this short form correlate highly with full-form IQ scores in several patient populations. We compared the full WAIS-R...

journal_title：Schizophrenia research

authors： Iverson GL,Guirguis M,Green P

更新日期：1998-03-10 00:00:00

abstract：:Normally, when two brief, non-startling auditory stimuli are presented 500 ms apart, with long (e.g., 10 s) interpair intervals, the positive potential occurring approx. 50 ms after the first stimulus (P50) is relatively large, and the P50 to the second stimulus is smaller. In schizophrenia patients, however, the P50 ...

journal_title：Schizophrenia research

authors： Clementz BA,Geyer MA,Braff DL

更新日期：1998-02-27 00:00:00

abstract：:Neurological Examination Abnormalities (NEA) are prevalent in schizophrenia, but the significance of this is obscured by methodological problems. The Neurological Evaluation Scale (NES), the most widely used structured neurological examination in schizophrenia research, has had limited study of its inter-rater reliabi...

journal_title：Schizophrenia research

authors： Sanders RD,Forman SD,Pierri JN,Baker RW,Kelley ME,Van Kammen DP,Keshavan MS

更新日期：1998-02-09 00:00:00

abstract：:The dopamine hypothesis of schizophrenia was formulated 30 years ago and postulates that the symptoms of schizophrenia are related to an increased central dopaminergic neurotransmission. The two fundamental assumptions that underlay the dopamine hypothesis of schizophrenia have received support from brain imaging stud...

journal_title：Schizophrenia research

authors： Farde L

更新日期：1997-12-19 00:00:00

abstract：:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...

journal_title：Schizophrenia research

authors： Harvey PD,Sukhodolsky D,Parrella M,White L,Davidson M

更新日期：1997-10-30 00:00:00

abstract：:The Wisconsin Card Sorting Test (WCST) is a multifactorial and complex test, and it involves so many different kinds of functions that it is difficult to understand why patients fail. Capacity of 'working memory' is possibly involved in the WCST performance and is considered a relevant factor responsible for the schiz...

journal_title：Schizophrenia research

authors： Stratta P,Daneluzzo E,Prosperini P,Bustini M,Mattei P,Rossi A

更新日期：1997-10-17 00:00:00

abstract：:Twenty-five schizophrenic patients diagnosed by DSM-III-R underwent event-related potentials and magnetic resonance imaging scans. Latency and amplitude of P300 waveform were measured using an auditory odd-ball paradigm. Anterior and posterior volumes of the superior temporal gyrus and medial temporal structure were m...

journal_title：Schizophrenia research

authors： Kawasaki Y,Maeda Y,Higashima M,Nagasawa T,Koshino Y,Suzuki M,Ide Y

更新日期：1997-08-29 00:00:00

abstract：:Past studies have shown that schizophrenic men tend to be impaired on the olfactory identification task. We examined individual differences in the olfactory function in relation to schizotypy. Healthy individuals who might carry latent liability for schizophrenia participated in olfactory identification and acuity tas...

journal_title：Schizophrenia research

authors： Park S,Schoppe S

更新日期：1997-08-29 00:00:00

abstract：:To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding...

journal_title：Schizophrenia research

authors： Shimizu E,Shirasawa H,Kodama K,Kuroyanagi H,Shirasawa T,Sato T,Simizu B

更新日期：1997-06-20 00:00:00

abstract：:Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2...

journal_title：Schizophrenia research

authors： Verga M,Macciardi F,Pedrini S,Cohen S,Smeraldi E

更新日期：1997-05-24 00:00:00

abstract：:We employed a simple and relatively undemanding task of monotone counting for the assessment of sustained attention in schizophrenic patients. The monotone counting task has been validated neuropsychologically and is particularly sensitive to right prefrontal lesions. We compared the performance of schizophrenic patie...

journal_title：Schizophrenia research

authors： Chen EY,Lam LC,Chen RY,Nguyen DG,Chan CK,Wilkins AJ

更新日期：1997-04-11 00:00:00

abstract：:In a study of 19 hospitalized chronic schizophrenic patients participating in a manualized skills training program, neuropsychological functioning was found to be an important mediating variable. Executive functioning capacity was positively associated with level of participation in the training groups, and deficits i...

journal_title：Schizophrenia research

authors： McKee M,Hull JW,Smith TE

更新日期：1997-02-28 00:00:00

abstract：OBJECTIVE:This is a comprehensive study designed to examine the association between specific clusters of neurological abnormalities and several clinically relevant aspects of schizophrenia such as positive and negative symptoms, neurocognitive deficits and psychosocial performance. METHODS:Thirty-seven clinically stab...

journal_title：Schizophrenia research

authors： Wong AH,Voruganti LN,Heslegrave RJ,Awad AG

更新日期：1997-02-07 00:00:00

abstract：:Earlier studies suggest that social competence has a higher predictive value for vocational outcome than psychopathology. These studies, however, show methodological shortcomings, including the fact that the instruments used for assessing social competence, psychopathology and work performance are strongly interrelate...

journal_title：Schizophrenia research

authors： Hoffmann H,Kupper Z

更新日期：1997-01-17 00:00:00

abstract：:Factor analysis was performed on OPCRIT checklist psychotic symptoms rated on 102 patients with DSM-III-R schizophrenia. An initial three-factor solution produced positive, negative, and disorganisation factors. However, application of the scree test suggested five substantive factors, with the positive factor dividin...

journal_title：Schizophrenia research

authors： Cardno AG,Jones LA,Murphy KC,Asherson P,Scott LC,Williams J,Owen MJ,McGuffin P

更新日期：1996-12-15 00:00:00

abstract：:Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizoph...

journal_title：Schizophrenia research

authors： Opeskin K,Dean B,Pavey G,Hill C,Keks N,Copolov D

更新日期：1996-11-15 00:00:00

abstract：:Arousal at 3-4 days of age was blindly assessed during the course of a standardized neurological examination of offspring born to index women with schizophrenic (n = 20), schizo-affective (n = 12), affective (n = 19) and unspecified functional (n = 4) psychoses, as well as 70 offspring born to control women with no hi...

journal_title：Schizophrenia research

authors： Schubert EW,Blennow G,McNeil TF

更新日期：1996-10-18 00:00:00

abstract：:This study was a preliminary open clinical trial aimed at exploring the hypothesis that estrogen may provide protection against schizophrenia in women. Eleven women with acute psychotic symptoms, as scored on the BPRS, SAPS and SANS, had 0.02 mg estradiol added to neuroleptic treatment for eight weeks. Their response ...

journal_title：Schizophrenia research

authors： Kulkarni J,de Castella A,Smith D,Taffe J,Keks N,Copolov D

更新日期：1996-07-05 00:00:00

abstract：:The relationship between social cognition (i.e., cognition for social stimuli) and ward behavior among individuals with chronic schizophrenia was investigated. Twenty-seven inpatients completed a battery of cognitive and social-cognitive tasks and were rated by staff on various indices of ward behavior. Overall, there...

journal_title：Schizophrenia research

authors： Penn DL,Spaulding W,Reed D,Sullivan M

更新日期：1996-07-05 00:00:00

abstract：:Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of n...

journal_title：Schizophrenia research

authors： Hoff AL,Harris D,Faustman WO,Beal M,DeVilliers D,Mone RD,Moses JA,Csernansky JG

更新日期：1996-05-01 00:00:00